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Title: Knowledge, Attitude, and Practice of Young Paediatricians About Chelation Therapyin Transfusion-Dependent Thalassemia Major Children
Authors: Misbah Fakih, Faisal Basheer, Saad Ateeq, Farooq Ikram, Hafsa Asad, Qamar uz Zaman Khan
Journal: Pakistan Armed Forces Medical Journal (PAFMJ)
Publisher: Army Medical College, Rawalpindi.
Country: Pakistan
Year: 2022
Volume: 72
Issue: 6
Language: English
DOI: 10.51253/pafmj.v72i6.4263
Keywords: ThalassemiaBlood transfusionChelation therapyIron overload
Objective: To determine the knowledge, attitude, and practice of young paediatricians about chelation therapy in transfusiondependent thalassemia major children.
Study Design: KAP survey
Place and Duration of Study: Six different hospitals in Rawalpindi and Islamabad Pakistan, from Jul 2019 to Jan 2020.
Methodology: We study enrolled a sample of 98 doctors. The study included all residents (R1, R2, R3, and R4) and senior registrars of the six hospitals, while those on leave for any reason like maternity or others were excluded. A pre-validated questionnaire was used to collect the data.
Results: Out of 98, maximum residents were of third-year (R3) 27(27.6%), followed by the second-year resident (R2) and senior registrar (SR) 19(19.4%). About 52(53.1%) residents reported that they did not have any thalassemia centre in their facility,with a maximum from Rawalpindi 65(66.3%). The study revealed that 61.2% study population had fair knowledge and attitude towards chelation therapy, while 22(22.4%) had poor and 16(16.3%) had satisfactory scores. The study revealed varied practices except for combination therapy, where 82.7% preferred it. The study showed a significant association between different categories of knowledge and attitude with professional levels, (p-value = 0.014).
Conclusion: The majority had a fair knowledge and attitude towards chelation therapy, while the practice varies mostly,except for the maximum preferred combination therapy for chelation. The study further concluded that with an increase in professional experience, knowledge, attitude and practice improved towards better treatment.
To determine the knowledge, attitude, and practice of young paediatricians regarding chelation therapy in transfusion-dependent thalassemia major children.
A Knowledge, Attitude, and Practice (KAP) survey was conducted using a pre-validated questionnaire among 98 young paediatricians (residents and senior registrars) in six hospitals in Rawalpindi and Islamabad, Pakistan, from July 2019 to January 2020. Data was analyzed using SPSS version 25.0, with quantitative variables summarized as Mean±SD and qualitative variables as frequency and percentages. A Chi-square test was used to find associations, with a p-value < 0.05 considered significant.
graph TD;
A["Ethical Approval & Administration Consent"] --> B["Develop & Validate Questionnaire"];
C["Recruit Sample 98 Paediatricians"] --> D["Administer Questionnaire"];
D --> E["Data Collection"];
E --> F["Data Analysis using SPSS"];
F --> G["Interpret Results"];
G --> H["Draw Conclusions"];
The study indicates that while young paediatricians generally possess fair knowledge and attitude towards chelation therapy, their practices are inconsistent, with a strong preference for combination therapy. The findings suggest that professional experience positively influences knowledge, attitude, and practice, highlighting a potential gap in formal training or adherence to standard guidelines. The lack of awareness regarding national guidelines is a concern that needs to be addressed.
- A majority (61.2%) of the study population had fair knowledge and attitude towards chelation therapy.
- Practices varied significantly, except for combination therapy, which was preferred by 82.7%.
- There was a significant association between knowledge and attitude categories with professional levels (p=0.014).
- With increased professional experience, knowledge, attitude, and practice improved.
- Approximately half of the participants were unaware of the Iron Chelation Therapy guidelines issued by the Thalassemia Federation of Pakistan.
The majority of young paediatricians have fair knowledge and attitude towards chelation therapy, but their practices are varied, with combination therapy being the most preferred approach. Professional experience correlates with improved knowledge, attitude, and practice, emphasizing the need for standardized training and adherence to guidelines to ensure optimal management of transfusion-dependent thalassemia major children.
- The study enrolled a sample of 98 doctors. (Confirmed in Methodology)
- The study was conducted from July 2019 to January 2020. (Confirmed in Methodology)
- 61.2% of the study population had fair knowledge and attitude towards chelation therapy. (Confirmed in Results)
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