Comparison of 18-FDG SUV Value with Bone Scintigraphy Findings in Diagnosed Cases of Malignancy with Sclerotic Bony Metastasis

Article Information

Title: Comparison of 18-FDG SUV Value with Bone Scintigraphy Findings in Diagnosed Cases of Malignancy with Sclerotic Bony Metastasis

Authors: Sana waqar, Tariq Saeed Siddiqui, Muhammad Mannan, Hafsa Sadiq, Haroon Sarfraz, Kiran Sarfraz

Journal: Pakistan Armed Forces Medical Journal (PAFMJ)

HEC Recognition History

Category	From	To
Y	2024-10-01	2025-12-31
Y	2023-07-01	2024-09-30
Y	2021-07-01	2022-06-30
Y	2020-07-01	2021-06-30
Y	1900-01-01	2005-06-30

Publisher: Army Medical College, Rawalpindi.

Country: Pakistan

Year: 2022

Volume: 72

Issue: 6

Language: English

DOI: 10.51253/pafmj.v72i6.7592

Keywords: Bone scintigraphyBone metastasis18-FDG PET/CTTc-99m SUV

Abstract

Objective: To determine the correlation of 18F-FDG SUV value with bone scintigraphy findings, i.e. uptake of Tc-99m in diagnosed cases of malignancy with sclerotic bone metastasis.
Study Design: Prospective longitudinal study.
Place and Duration of Study: Armed Forces Institute of Radiology and Imaging, Rawalpindi Pakistan, from Sep 2020 to Mar 2021.
Methodology: This study included 30 patients of age 18 to 80 years who had sclerotic bone metastasis as confirmed in histopathology. All patients underwent whole-body PET/CT scanning to evaluate sclerotic bone metastasis and determined 18-FDG SUV after 5MBq/kg body weight of 18-FDG was injected. After two weeks of PET/CT scan, Tc-99m bone scintigraphy was carried out, and SUV of Tc-99m was determined after 20-25mCi technetium-99 methylene disphosphonate was injected, and the correlation was assessed between SUV of 18-FDG and Tc-99m.
Results: The mean 18-FDG SUVmax and mean Tc-99m SUVmax, were, 21.31±8.77g/ml and 15.29±6.49g/ml respectively.21(70%) lesions on 18-FDG PET/CT and 8(26.7%) on Tc-99m bone scintigraphy were metastatic in bones. 18-FDG SUV on PET/CET and Tc-99m SUV on bone scintigraphy correlated positively with each other, and this correlation was found to be statistically significant (r=0.491, p=0.006).
Conclusion: 18-FDG SUV PET/CT significantly correlated with Tc-99m SUV on bone scintigraphy and helped detect metastatic lesions earlier and modulate treatment response.Keywords: Bone metastasis, Bone scintigraphy, 18-FDG PET/CT, Tc-99m SUV.

Disclaimer: The following sections are produced through an intensive multi-stage analytical pipeline developed by DefinePK, utilizing advanced natural-language processing, domain-specific knowledge models, and automated cross-referencing systems. Despite the rigor and computational effort involved, the generated summary may still contain inaccuracies or incomplete interpretations. Users are strongly advised to verify all critical information against the original paper and its authoritative sources.

Research Objective

To determine the correlation of 18F-FDG SUV value with bone scintigraphy findings (uptake of Tc-99m) in diagnosed cases of malignancy with sclerotic bone metastasis.

Methodology

Prospective longitudinal study conducted at Armed Forces Institute of Radiology and Imaging, Rawalpindi Pakistan, from September 2020 to March 2021. Included 30 patients with histologically confirmed sclerotic bone metastasis. Patients underwent whole-body PET/CT scanning to determine 18-FDG SUV, followed by Tc-99m bone scintigraphy two weeks later to determine Tc-99m SUV. Correlation between SUV of 18-FDG and Tc-99m was assessed.

Methodology Flowchart

                        graph TD
A[Patient Selection Sclerotic Bone Metastasis] --> B[PET/CT Scan 18-FDG SUV];
B --> C[Two Weeks];
C --> D[Bone Scintigraphy Tc-99m SUV];
D --> E[Data Analysis Correlation];
E --> F[Conclusion];

Discussion

The study indicates a positive correlation between 18-FDG SUV on PET/CT and Tc-99m SUV on bone scintigraphy. 18-FDG PET/CT detected metastatic lesions more frequently than bone scintigraphy. The findings suggest that 18-FDG PET/CT may be more helpful in detecting osteosclerotic bony metastasis compared to bone scintigraphy.

Key Findings

The mean 18-FDG SUVmax and mean Tc-99m SUVmax were 21.31±8.77g/ml and 15.29±6.49g/ml, respectively. 21 (70%) lesions on 18-FDG PET/CT and 8 (26.7%) on Tc-99m bone scintigraphy were metastatic in bones. 18-FDG SUV on PET/CET and Tc-99m SUV on bone scintigraphy correlated positively with each other (r=0.491, p=0.006).

Conclusion

18-FDG SUV PET/CT significantly correlated with Tc-99m SUV on bone scintigraphy and helped detect metastatic lesions earlier and modulate treatment response.

Fact Check

1. Study duration: September 2020 to March 2021 - Confirmed in Methodology section.
2. Sample size: 30 patients - Confirmed in Methodology and Results sections.
3. Correlation coefficient (r) between 18-FDG SUVmax and Tc-99m SUVmax: 0.491 - Confirmed in Results and Discussion sections.

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