Comparison of the Efficacy of Tazarotene 0.1% Cream Versus Clindamycin 1% Gel in the Treatment of Acne Vulgaris

Article Information

Title: Comparison of the Efficacy of Tazarotene 0.1% Cream Versus Clindamycin 1% Gel in the Treatment of Acne Vulgaris

Authors: Afnan Bin Haq, Zafar Iqbal Shaikh, Sadia Malik, Amir Ashraf, Syed Sajid Ali Shah, Ayesha Anwar

Journal: Pakistan Armed Forces Medical Journal (PAFMJ)

HEC Recognition History

Category	From	To
Y	2024-10-01	2025-12-31
Y	2023-07-01	2024-09-30
Y	2021-07-01	2022-06-30
Y	2020-07-01	2021-06-30
Y	1900-01-01	2005-06-30

Publisher: Army Medical College, Rawalpindi.

Country: Pakistan

Year: 2022

Volume: 72

Issue: 5

Language: English

DOI: 10.51253/pafmj.v72i5.6764

Keywords: Acne VulgarisClindamycinDermatologyGAGS scoreTazarotene

Abstract

Objective: To compare the efficacy of Tazarotene 0.1% cream versus Clindamycin 1% gel in treating acne vulgaris.
Study Design: Quasi-experimental study.
Place and Duration of the Study: Dermatology Department, Pak Emirates Military Hospital, Rawalpindi Pakistan, from Jan to Jul 2018.
Methodology: One hundred and fifty-four patients of both genders who had moderate acne vulgaris for more than four weeks were divided into two Groups. In both Groups, patients applied one-fourth fingertip unit of Tazarotene 0.1% cream in the evening once daily and Clindamycin 1% gel over the affected area in the morning once daily for 12 weeks. The Global Acne Grading System Score (GAGS score) was used for severity and efficacy assessment.
Results: The majority of the patients belonged to 13-25 years of age, i.e., 61(79.2%) and 54(70.1%) in Group-A (Tazarotene 0.1% cream) and Group-B (Clindamycin 1% gel), respectively. The efficacy of topical Tazarotene cream (0.1%) was better than topical Clindamycin 1% gel, and the difference was statistically significant with a p-value less than 0.01. GAGS score &lt;10 was observed in 54.5% and 33.8% of patients in Group-A and Group-B, respectively.
Conclusion: Topical Tazarotene cream (0.1%) was more effective than topical Clindamycin 1% gel in treating acne vulgaris.

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Research Objective

To compare the efficacy of Tazarotene 0.1% cream versus Clindamycin 1% gel in treating acne vulgaris.

Methodology

Quasi-experimental study conducted at the Dermatology Department, Pak Emirates Military Hospital, Rawalpindi Pakistan, from Jan to Jul 2018. One hundred and fifty-four patients with moderate acne vulgaris were divided into two groups. Group A applied Tazarotene 0.1% cream daily in the evening, and Group B applied Clindamycin 1% gel daily in the morning for 12 weeks. The Global Acne Grading System Score (GAGS score) was used for severity and efficacy assessment.

Methodology Flowchart

                        graph TD;
    A["Recruit 154 patients with moderate acne vulgaris"] --> B["Divide patients into two groups: Group A Tazarotene"] and Group B["Clindamycin"]);
    B --> C["Apply treatment daily for 12 weeks"];
    C --> D["Assess efficacy using GAGS score"];
    D --> E["Analyze results and compare efficacy"];
    E --> F["Conclude Tazarotene is more effective"];

Discussion

Acne vulgaris is a common inflammatory skin disease. Tazarotene, a synthetic retinoid, has anti-inflammatory and anti-proliferative actions and normalizes keratinocyte differentiation. The study found Tazarotene to be more efficacious than Clindamycin, aligning with some previous research. While Tazarotene can cause irritation, it was generally well-tolerated. Acne vulgaris significantly impacts quality of life, and treatment with these medications showed improvement.

Key Findings

Topical Tazarotene cream (0.1%) was found to be more effective than topical Clindamycin 1% gel in treating acne vulgaris, with a statistically significant difference (p-value < 0.01). In Group A (Tazarotene), 54.5% of patients achieved a GAGS score <10, compared to 33.8% in Group B (Clindamycin).

Conclusion

Topical Tazarotene cream (0.1%) is a more preferable and effective option than topical Clindamycin 1% gel for treating acne vulgaris.

Fact Check

1. The study was conducted from January to July 2018. (Confirmed in Methodology section)
2. The study included 154 patients divided into two groups of 77 each. (Confirmed in Methodology section)
3. Efficacy was defined as a Global Acne Grading System (GAGS) score <10 after 12 weeks of treatment. (Confirmed in Methodology section)

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