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Title: Macular Thickness Decreases with Age in Normal Eyes: A Study On Macular Thickness Map Protocol on the Oct
Authors: Tooba Bint Tahir, Waqar Muzzaffar, Mahum Faheem, Ammarah Ashraf
Journal: Pakistan Armed Forces Medical Journal (PAFMJ)
Publisher: Army Medical College, Rawalpindi.
Country: Pakistan
Year: 2022
Volume: 72
Issue: Supplementary 2
Language: English
DOI: 10.51253/pafmj.v72iSUPPL-2.7599
Keywords: Optical Coherence TomographyETDRSMacular thickness
Objective: To evaluate the normal macular thickness and how it varies with age in the eyes of healthy subjects using macular map protocol on Spectral-Domain Optical Coherence Tomography (SD-OCT).
Study Design: Cross-sectional study.
Place and Duration of Study: Armed Forces Institute of Ophthalmology, Rawalpindi Pakistan, from Jun 2020 to Sep 2021.
Methodology: Our study included one thousand seven hundred and four eyes (1704) of healthy subjects. They underwent imaging with macular thickness map protocol using Topcon Spectral-Domain Optical Coherence Tomography (SD-OCT). According to the macular thickness map, protocol macular area was subdivided into nine ETDRS fields. Measurement of macular thickness and its variations with age were determined. Pearson correlation was applied to identify the relationship between age and macular thickness of layers.
Results: Our study revealed a negative relationship which was statistically significant between macular thickness and age for all the ETDRS regions. Results showed a mean macular thickness of 274.90 ± 15.18. The female gender was found to have greater macular thickness than males (p-value 0.002).
Conclusion: This study concluded a significant decrease in macular thickness with age. This is the first normative study using Topcon SD-OCT and macular map protocol for macular thickness measurement done in the Pakistani population.
To evaluate the normal macular thickness and how it varies with age in the eyes of healthy subjects using macular map protocol on Spectral-Domain Optical Coherence Tomography (SD-OCT).
Cross-sectional study involving 1704 healthy eyes from subjects aged 10 to 80 years. Macular thickness was measured using the macular thickness map protocol on Topcon Spectral-Domain Optical Coherence Tomography (SD-OCT), with the macula subdivided into nine ETDRS fields. Pearson correlation was used to analyze the relationship between age and macular thickness.
graph TD;
A["Recruit Healthy Subjects"] --> B["Perform Ocular Examination & Refraction"];
B --> C["Obtain Informed Consent"];
C --> D["Perform SD-OCT Imaging with Macular Thickness Map Protocol"];
D --> E["Discard Low Quality Scans"];
E -- Valid Scans --> F["Measure Macular Thickness in Nine ETDRS Fields"];
F --> G["Analyze Data using SPSS"];
G --> H["Apply Pearson Correlation for Age and Thickness"];
H --> I["Compare Thickness between Genders using t-test"];
I --> J["Report Findings"];
The study concludes that macular thickness significantly decreases with age, consistent with previous research on age-related cell loss in the retina. The findings highlight the utility of Topcon SD-OCT with the macular map protocol for normative studies in the Pakistani population and suggest potential gender-based differences in macular thickness.
A statistically significant negative relationship was found between macular thickness and age across all ETDRS regions. The mean macular thickness was 274.90 ± 15.18 µm. Female gender was associated with greater macular thickness than males (p-value 0.002).
There is a significant decrease in macular thickness with age in healthy eyes. This study provides the first normative data using Topcon SD-OCT and the macular map protocol for macular thickness measurement in the Pakistani population.
- The study included 1704 eyes of healthy subjects.
- The mean macular thickness was found to be 274.90 ± 15.18 µm.
- Female gender was associated with greater macular thickness than males with a p-value of 0.002.
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