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?POTENTIAL ANTIBACTERIAL AGENTS PART-V. SYNTHESIS AND STRUCTURAL CHARACTERIZATION OF SOME NEW 3-ARYL 7H, 6-(ARYL) SH-l, 2, 4-TRIAZOLO [3, 4-b]-1, 3, S-THIADIAZINES

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Title: ?POTENTIAL ANTIBACTERIAL AGENTS PART-V. SYNTHESIS AND STRUCTURAL CHARACTERIZATION OF SOME NEW 3-ARYL 7H, 6-(ARYL) SH-l, 2, 4-TRIAZOLO [3, 4-b]-1, 3, S-THIADIAZINES

Authors: Tahira B Sarfrazt, Shaheen A Husain, Najma Murtaza, Billa S Slddlqui

Journal: Pakistan Journal of Scientific and Industrial Research (Series B: Biological Sciences)

HEC Recognition History
Category From To
Y 2023-07-01 2024-09-30
Y 2022-07-01 2023-06-30
Y 2021-07-01 2022-06-30
Y 2020-07-01 2021-06-30
Y 1900-01-01 2005-06-30

Publisher: PCSIR Scientific Information Centre

Country: Pakistan

Year: 2000

Volume: 43

Issue: 6

Language: English

Keywords: Fused ring heterocyclic compounds Triazolothiadiazines Intramolecular Mannich condensation.

Categories
Chemical Biology (10) Organic Chemistry (862) Pharmacology (22872) Pharmaceutical Science (262) Medicinal Chemistry (1249)

Abstract

N-(Substituted benzoyl) thiosernicarbazides lla-e were treated with sodium hydroxide solution to give 3-aryl-S- e mercapto-4H-i ,2,4-triazolc 111a-e which were subjected to Mannich Reaction in presence of2-0Cll;, 4-NOz and 2- OeH) substituted anilines to give 3-aryl 7H, 6-(aryl) SH-I,2,4-triazolo [3,4-b]-I,3,S-thiadiazines IVa-h. The com- pounds, IVa-h were compared with oxytetracycline and ampiclox (standard antibiotics) for their antibacterial activity.

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