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?POTENTIAL ANTIBACTERIAL AGENTS PART-IV. SYNTHESIS OF NEW 1[2-PYRIMIDINO ]_. AMINO-METHYL BENZIMIDAZOLES AND 1,2,. 3 BENZOTRIAZOLES

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Title: ?POTENTIAL ANTIBACTERIAL AGENTS PART-IV. SYNTHESIS OF NEW 1[2-PYRIMIDINO ]_. AMINO-METHYL BENZIMIDAZOLES AND 1,2,. 3 BENZOTRIAZOLES

Authors: Shaheen A Hussainv, Tahira B Sarfaraz, Najma Murtaza, Shaheen Faiai

Journal: Pakistan Journal of Scientific and Industrial Research (Series B: Biological Sciences)

HEC Recognition History
Category From To
Y 2023-07-01 2024-09-30
Y 2022-07-01 2023-06-30
Y 2021-07-01 2022-06-30
Y 2020-07-01 2021-06-30
Y 1900-01-01 2005-06-30

Publisher: PCSIR Scientific Information Centre

Country: Pakistan

Year: 1998

Volume: 41

Issue: 2

Language: English

Keywords: Antibacterial activityMannich basesHydroxybenzimidazole.

Categories
Chemical Biology (10) Organic Chemistry (862) Pharmacology (22872) Pharmaceutical Science (262) Medicinal Chemistry (1249)

Abstract

Condensation reaction of (IS)-2(a-hydroxy ethyl) benzimidazole (I), 2-hydroxymethyl benzimidazole (II) and 1,2,3 benzotriazole (III) with pyrimidine viz: 2-aminopyrimidine (IV-a) and4, 6-dimethyl-pyrimidine (IV-b) under thecondi- tion of Mannich reaction afforded the hitherto unreported substituted l-arninomethyl (hydroxyalkyl) benzimidazoles and l-aminomethyl benzotriazoles which were assigned the structures (Va-d) and (VIa-b) on the basis of their lR, IH-NMR and HREIMS spectral studies. Antibacterial activity was also evaluated.

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