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SYNTHESIS OF NITROGEN-OXYGEN HETEROCYCLES FROM CARBOHYDRATE PRECURSOR

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Title: SYNTHESIS OF NITROGEN-OXYGEN HETEROCYCLES FROM CARBOHYDRATE PRECURSOR

Authors: M. ARDEL RAHMAN, M. EL SADEK, S. ABDEL BAKY , N. EL SOCCARY

Journal: Pakistan Journal of Scientific and Industrial Research (Series B: Biological Sciences)

HEC Recognition History
Category From To
Y 2023-07-01 2024-09-30
Y 2022-07-01 2023-06-30
Y 2021-07-01 2022-06-30
Y 2020-07-01 2021-06-30
Y 1900-01-01 2005-06-30

Publisher: PCSIR Scientific Information Centre

Country: Pakistan

Year: 1994

Volume: 37

Issue: 8

Language: English

Keywords: TetrahydroindoleBenzoylhydrazoneOxadiazole.

Categories
Heterocyclic Chemistry (35) Carbohydrate Chemistry (8) Chemical Synthesis (47) Organic Chemistry (862) Medicinal Chemistry (1249)

Abstract

6, 6-Dimethyl-4-oxo-4, 5, 6, 7-tetrahydroindol-2-carboxaldehyde (2) condensed with benzoylhydrazine to affordthe corresponding benzoyl hydrazone derivative '3'. Oxidative cycJization of3 gave the corresponding 1,3, 4-oxadiaz<;>lemercuriccomplex '4'. On the other hand, the methylated aldehyde '5' condensed with a number of aryl and acylhydrazinesto afford the corresponding hydrazones '6-18'. Oxidative cycJization of the acylhydrazones gave the corresponding1,3, 4-oxadiazoles '19-27'. The structures were confirmed by rR, 1H-NMR and mass spectra.

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