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Abstract

Objective: The aim of this study was to find out the effects of two differentgroups of causes of pulmonary hypertention (PH) on mean plateletvolume(MPV), left and right ventricles by echocardiography.Methodology: This case control study was conducted in Cardiology Departmentof Ain Shams University Hospital Cairo , Egypt from 1st January 2015 to 30thJune 2015.The study included consecutive patients from outpatient clinicssuffering from pulmonary hypertension, chronic obstructive pulmonary disease(COPD) and rheumatic mitral stenosis (RMS). The healthy persons werematched in age and gender. Non COPD, non-rheumatic constituted the controlgroup. Echocardiographic study, respiratory function tests and mean plateletvolume (MPV) of study population were done. P<0.05 was taken as significant.Results: This study included ninety persons. About thirty patients had COPDandthirty patients had rheumatic mitral stenosis. Additionally thirty healthyindividuals were also enrolled. MPV was 11.29 ± 2.39 fl in patients sufferingfrom COPD, 11.06 ± 1.56 fl in patients with RMS and 9.61 ± 1.02 fl in controlpersons (p=0.007). As regards to the left side of the heart there were significantstatistical difference only in end systolic dimension, aortic root and left atrialdimensions between the three groups. RMS effected the right side of the heartsignificantly . When subgroup analysis was done, patients with rheumatic mitralstenosis showed significant differences between all the studied parameters whilepatients with COPD did not show this significance.Conclusions: MPV is higher in patients with different causes of PH than thenormal subjects but the effect on both sides of the heart are different according tothe cause of PH.Key words: Pulmonary hypertension, rheumatic mitral stenosis, COPD