DefinePK

Abstract

Objective: The objective of study was to evaluate regional myocardial function bystrain (S) echocardiography in patients with or without diastolic dysfunction andhealthy individuals with normal left ventricular ejection fraction.Methodology: This crossectional comparative study was conducted atdepartment of cardiology, Jinnah Hospital Lahore, from January 2012 to October2012. Thirty hypertensive and thirty healthy individuals were enrolled in study.Strain Doppler echocardiography was used to evaluate 30 patients withhypertension and 30 age matched control subjects. With pulsed-wave Doppler,mitral inflow velocities were obtained to measure diastolic E and A waves, E/Aratio, and E-wave deceleration time(DT); with tissue doppler imaging earlydiastolic (Ea), and late diastolic velocities(Aa) and longitudinal peak systolicstrain (S ) values were measured.Results: Mean age of study population in control subjects (Group A) 45±6 yearsand in hypertensive subjects (Group B) 53±7 years. Among control subjects, 18were males (60%) and 12(40%) were females. In hypertensive subjects16(53.3%) were males while 14(46.6%) were females. No difference was notedregarding age, sex, body surface area and heart rate. Among the hypertensivepatients, 14(46.6%) were having diastolic dysfunction while 16(53.3%) patientwere without diastolic dysfunction. Peak strain values were significantlydecreased in patients with hypertension with or without diastolic dysfunction ascompared to healthy individuals.Conclusion: Hypertensive patients with or without diastolic dysfunction havereduced left ventricular systolic longitudinal strain.