DefinePK

Abstract

Objective: The aim of the present study was to evaluate the role of C-reactiveprotein (CRP), leukocyte count and myeloperoxidase (MPO) in predictingadverse outcomes in acute coronary syndrome patients.Methodology: Ninety consecutive patients with acute coronary syndrome (ACS)were enrolled from Coronary Care Unit of Shaikh Zayed Hospital, Lahore fromJanuary 2012 to April 2013. Baseline leukocyte count was determined by Abacuscell counter while CRP and MPO levels were determined by using commerciallyavailable enzyme immunoassays. Mortality and adverse cardiac events wererecorded for a follow up period of 6 months.Results: Out of ninety patients 65 (72.2%) were males. Mean age of patients was56.25±13.01 years (male patients 55.43±14.02 while female patients58.4±9.88). Number of adverse events was highest (18.6%) in CRP > mediancategory, followed by leukocyte count > median (17.9%) and MPO > mediancategory (17.1%), respectively. Adverse event rate was found to be significantlyhigher (p = 0.043) in CRP > median category as compared to CRP < mediancategory. Adverse event rate was also higher (p = 0.08) (clinically significant) in> median category of leukocyte count but in case of MPO level it did not reachlevel of statistical or clinical significance (p = 0.12).Conclusion: CRP is a predictor of adverse outcome in acute coronary syndromepatients and may serve as a marker in prognosis of ACS. Further studies withlarge sample size are required for confirmation of predictive role of leukocytecount.