DefinePK

Abstract

                                                                                       Abstract
Objective: To assess developmental delay in children with osteogenesis imperfecta (OI).
Study design: Cross-sectional study
Place and duration of study: Developmental and Behavioural Paediatrics Department and Osteogenesis Imperfecta clinic, Paediatric Medicine, University of Child Health Sciences, The Children’s Hospital Lahore. The study duration was 6 months from April, 2022 to September, 2022.
Patients and Methods: A sample of 50 children (aged 5 weeks to 6 years) having OI was collected through purposive sampling. Schedule of Growing Skills II (SGS-II) was administered to measure developmental profile. Demographic questionnaire including age, gender, age at the time of giving bisphosphonate injection, etc. was also administered.
Results: Majority of the patients with OI had delay in locomotion (86%, n=43), cognition (84%, n=42), vision (78%, n=39), speech and language (76%, n = 38), interactive skills (70%, n = 35) and manipulative skills (70%, n = 35). Half of patients had delay in active postural skills (50%, n=25) and hearing and language skills (54%, n=27). Chronological age and age at the time of 1st injection (p<0.05) were positively correlated with all skill areas.
Conclusion: Developmental profile of children with OI showed significant delay in majority of skill areas that could affect their quality of life and schooling.