DefinePK

Abstract

Helicobacter pylori ( H. pylori ) infection affects millions of people worldwide, including Middle East. There are several treatment regimens available to treat the illness caused by this organism. In order to eradicate the H. pylori infection in the Middle East, proton pump inhibitor (PPI)-based regimens are increasingly being reported in the literature, which was the focus of this study. We studied the regimens used in various nations to identify the most effective and widely used (PPI)-based regimen in clinical settings. Although a PPI and two antibiotics for 10- to 14-day course of treatment have traditionally been used to treat such infections, there are now several alternatives. Quadruple therapies like bismuth have demonstrated improved H. pylori eradication. Thus, they are suggested as primary treatments in Middle Eastern regions where resistance rates are lower. Quadruple therapy that includes bismuth has shown superior H. pylori eradication over traditional triple regimens. As a result, it has been recommended as first-line treatment in Middle Eastern countries where resistance is less common.