DefinePK

Abstract

Objectives: To evaluate the incidence of thyroid dysfunction and to investigate the chemical changes in serum lipidsunder the influence of thyroid dysfunctions.Material and Methods: This study was conducted in Pakistan Medical Research Centre (PMRC), Khyber MedicalCollege, Peshawar, Pakistan from January 2011 to August 2014 . Blood samples and data were collected from patientsattending the Institute of Radioactive Nuclear Medicine (IRNUM) Peshawar, Pakistan. A Total of 600 cases were includedin this study out of which 214 were euthyroid, 195 and 191 were hyperthyroid and hypothyroid respectively.Results: The study subjects are divided into three groups on the basis of hormonal assay for the three parametersi.e. thyroid stimulating hormone (TSH), tri-iodo thyronine (T3), tetra-iodo thyronine (T4). The Euthyroid group whichincludes healthy individuals serves as control. The level of significance chosen as 0.05 and p-values were calculated.Conclusion: Thyroid dysfunctions are more prevalent in females, total Cholesterol (TC), Triglyceride (TG) and LowDensity Lipo Protein Cholesterol (LDL-C) levels are positively correlated with hyperthyroidism as well as hypothyroidism,whereas High Density Lipo Protein Cholesterol (HDL-C) has no significant relation with thyroid dysfunction