DefinePK

Abstract

Objective To compare the efficacy of combination of intralesional corticosteroid injection and cryotherapy with intralesional corticosteroid injection alone in patients of keloid. Methods A clinical trial was carried out in the department of Dermatology and Venereology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh for duration of January 2013 to August 2013. About 30 patients (group A) were treated with intralesional triamcinolone acetonide with cryotherapy and 30 patients (group B) were treated with intralesional triamcinolone acetonide. Results Improvement rate was highest for the lesions on the chest, which was 18 (34.6%) and lowest for back 3 (5.8%). Out of all patients from group A, the mean size of the lesions were 8.17cm, 5.90 cm, 4.32 cm, and 3.57 cm at 1st visit, 2nd visit, 3rd visit and 4th visit, respectively. In group B, the mean size of the lesions was 7.50 cm, 4.92 cm, 3.00 cm, and 4.75 cm at 1st visit, 2nd visit, 3rd visit and 4th visit, respectively. Among the patients of group A and B, 27 (90%) and 25 (83.3%) cases improved, respectively. Conclusion Each of the treatment was individually effective in the treatment of keloid but study with a larger group of patients for longer period may result in superior outcome in clinical practice through improved compliance.