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Abstract

Objective: To determine the frequency of depression in functional dyspepsiapatients.Methodology: 247 patients satisfying Rome III definition of functional dyspepsiawere assessed for depression applying NICE criteria for diagnosis ofdepression. Subjects with alarm features in history and examination were excludedas well as patients with any co morbid condition to reduce bias. Thepatients were put into various groups depending upon patient's predominantsymptoms. The frequency of depression was assessed in dyspeptic patients.Furthermore strength of association was also checked between various variablesand depression in dyspeptic patients.Results: Among 247 patients, 107 patients were female and 140 patientswere male. Mean age and mean duration of illness was 35.84±11 years and2.33±2.38 years respectively. Epigastric pain syndrome (EPS) was present in28.9% of the patients, postprandial distress syndrome (PDS) was present in28.5% of the patients and 42.7% had both the symptoms. Depression wasdiagnosed in 75.3% of functional dyspepsia patients. We found significantassociation between female gender and depression with a p value of 0.009.In univariate analysis significant association was again found between femalegender and depression (OR 2.32, p value 0.01) but duration of the disease anddyspepsia group had no association.Conclusion: Frequency of depression was found high in functional dyspepsiapatients. Therefore every functional dyspepsia patient should be thoroughlyassessed for depression.