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Abstract

Background: Old age, obesity and androgens are more vulnerable to prostatic disorders. Benign Prostatic Hyperplasia (BPH) is a common problem for adults. Objectives: To determine the morphological changes of prostate gland and effects of Estrogen levels in obese versus non-obese males with BPH. Methods: A cross sectional study was conducted on sixty patients in an emergency clinic of Dr. Ruth Pfau, Dow university of Health Sciences, Karachi from 17th May 2019 to 15th February 2020(IRB-1182/DUHS/approval/2019). All selected patients have BPH and assessed by Global prostate side effect score >7. Patients with BPH were divided into two groups obese and non-obese, as indicated by Body Mass Index (BMI) and waist circumference (WC). Group A (obese) had BMI ≥ 25; WC ≥ 90cm and group B (non-obese) had BMI < 25; WC < 90cm. Trans rectal ultrasound and estimation of serum Estrogen was performed to analyzed the length, width, diameter and volume of prostate. Results: The mean prostate volume was higher in the obese group 36.13±3.673ml while in non-obese group it was 31.21±6.771 ml, which was found to be statistically significant (p = 0.001). The mean Estrogen levels in obese group were 328.21±115.05pmol/l, while in non-obese group it was 309.72±73.62pmol/l (p=0.462). Significant positive correlation was observed (r = 0.279, p- =0.031) between prostate volume and serum Estrogen levels in study participants. Conclusion: Obesity and serum Estrogen levels had significant effect on the prostate volume as compared to non-obese participants within same age group which showed significant moderate positive correlation with prostate volume in obesity.