DefinePK

Abstract

Objective: To compare the effect of Triamcinolone versus Platelet Rich Plasma (PRP) injection intraorally for improvingtrismus in Oral Submucous Fibrosis (OSMF).Study Design and setting: Randomized double-blind comparative study, conducted at ENT department of PNS ShifaHospital, Karachi from 1st June 2015 to 30th June 2016.Methodology: Eighty patients with trismus due to oral submucous fibrosis were divided randomly into two groups, ‘A’and ‘B’ of 40 patients each. In Group A, Inj. Triamcinolone 40mg (1 ml) was injected into the sub-mucosal plane in theretro-molar trigone area and into the fibrous bands along the soft palate on multiple sites, weekly for 6 weeks. In group BInj. PRP 1ml weekly was administered for 6 weeks along the same site. Vernier calipers were used to precisely measurethe Maximum Interincisal Distance (MIID) in cms before and after the treatment.Result: There was a male preponderance in the study group with a male to female ratio of 5.1:1. In group ‘A’ mean pretreatmentMIID was 2.3±0.7 cms, while in group ‘B’, it was 2.2± 0.5 cms. After completion of 6 weeks treatment the meanMIID improved in group ‘A’ to 3.08 ± 0.8cms, and in group ‘B’ to 3.22± 0.5cms. The mean improvement in MIID in group‘A’ was 0.783± 0.25cms compared to 1.01± 0.05 cms in group ‘B’ (p < 0.05).Conclusion: Intraoral injection of PRP is more effective than Triamcinolone in improving trismus due to OSMF.