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Abstract

Objective: To evaluate weight changes on the liver of male (albino wistar) rats induced by erythromycin. To assess theoutcome of aqueous Neem leaf extract on erythromycin induced hepatic injuries.Methodology: Eighty male albino wistar rats were taken randomly and were divided into 4 groups of 20 animals each.Group A as a control group. Group B rats were treated with erythromycin drug. Group C rats were treated with erythromycinalong with Aqueous Neem leaves extract. Group D were given only Aqueous Neem leaves extract. Body weight of animalswas recorded initially and also after experimentation. After 14 days animals were sacrificed, liver weight was also recorded.Results: The liver of erythromycin treated animals group B were little bigger in size and more reddish. However erythromycinplus Neem treated animals of group C livers were almost like liver of control group A and only Neem given group Danimals, liver were exactly same appearance like control group A.Rise in absolute and relative weight of liver was becauseof drug toxicity.Conclusion: Its established from this recent study that Aqueous Neem leaves extract being a powerful antioxidant, decreasedoxidative stress and hepatic injury caused by erythromycin