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Abstract

Objective: To determine the outcome of wilms tumors among children in our center and compare the results of treatmenton the basis of management proposed by the National Wilms tumor study board (NWTS) and the Societe internationalD’oncologie pediatrique (SIOP)Patients and methods:- This study includes 49 children who presented to the Aga Khan University Hospital(AKUH) withwilms tumors from January 1988 to December 2015 (aged 0-16 years). Patients were further divided according to thetreatment strategies they received i.e NWTS and SIOP. Data was analyzed using SPSS 10.Results:-.A total of 49 patients (57%male and 43% female) were included in the study. Majority of the cases (56%) werebetween 1-5 years. The tumors mostly presented on the right side (65%).The diagnostic work up of the patients mainlyinvolved CT imaging (69%).35% of children in the SIOP group presented with stage 3 diseases whereas in the NWTSgroup 42% presented with stage 1 disease. In the SIOP group 4 (14%) patients had disease reoccurrence and 2 (7%) patientsdied. In the NWTS group 2(10%) patients had disease reoccurrence and 1 (5%) patient expired. A 5 year survival rate ofboth groups was calculated to be more than 80%. Mean follow up in SIOP group was 119 months and In NWTS groupwas 114 months.Conclusions:- Wilms tumors are curable in the majority of the patients even with limited resource as in our country. TheNWTS and SIOP treatment approaches are almost equally effective at our center however adherence to a single treatmentis mandatory for effective treatments.