DefinePK

Abstract

Introduction


Gastro Oesophageal Reflux Disease (GORD) is a chronic and relapsing disease, defined as "Failure of antireflux barrier, allowing reflux of gastric contents into the esophagus".1 According to the Genval Workshop, this term should be used to include all individuals who are exposed to the risk of physical complications from Gastro-esophageal reflux or who experience clinically significant impairment of health - related well being (quality of life) due to reflux -related symptoms.2
The most commonly experienced symptoms are retrosternal burning or heartburn and duration of symptoms varies from more than three months to 10 years. Upper GI endoscopy is used as the most common first line of investigation. The correlation between reflux symptoms and endoscopy-positive GORD is poor and most GORD patients aged