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Title: Alterations in the level of Neurotransmitters associated with the chronic treatment of Antipsychotic Drugs
Authors: Afshan Wasti , Nikhat Ahmed Siddiqui
Journal: Journal of Pakistan Medical Association
Publisher: Pakistan Medical Association.
Country: Pakistan
Year: 2010
Volume: 60
Issue: 8
Language: English
Abstract
Objective: To investigate the alterations in different neurotransmitters particularly dopamine and serotonin in various regions of rat brain.
Methods: By using HPLC-ECD, the concentration of dopamine, their metabolites (DOPAC, HVA), serotonin, their precursor (tryptophan), and metabolites (5-HIAA) were determined in different regions such as hypothalamus, cortex, midbrain and striatum. In addition, tryptophan pyrrolase enzyme activity and the concentration of tryptophan were also determined in liver samples, following chronic (21 days I/M) treatment of haloperidol and clozapine (of both commercially available and purified form) in an animal model.
Results: Significant alterations were observed in the level of neurotransmitters in different regions of rat brain. In response to haloperidol treatment, the level of dopamine was observed to be significantly increased in hypothalamus, cortex and striatum but in midbrain the concentration was slightly decreased, While a significant increase (p
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