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Effect of Chioroquine on Liver Weight of developing Albino Rats

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Title: Effect of Chioroquine on Liver Weight of developing Albino Rats

Authors: A. Zahid , T. S. Abidi 

Journal: Journal of Pakistan Medical Association

HEC Recognition History
Category From To
Y 2024-10-01 2025-12-31
X 2023-07-01 2024-09-30
X 2022-07-01 2023-06-30
X 2021-07-01 2022-06-30
X 2020-07-01 2021-06-30
W 2012-07-01 2020-06-30
X 2011-05-13 2012-06-30
Y 1900-01-01 2005-06-30

Publisher: Pakistan Medical Association.

Country: Pakistan

Year: 2003

Volume: 53

Issue: 1

Language: English

Categories
Experimental Biology (12) Animal Science (6960) Toxicology (7198) Pharmacology (22872) Hepatology (3886)

Abstract

Abstract


Objective:To see the effect of chioroquine on liver weight of developing albino rats.
Methods:Twenty four pregnant female albino rats were used and divided in 4 groups. They were kept in Animal House of Post Graduate Medical Institute, Lahore. Total gestational period in rats ranges from 20-22 days, which in this study was divided into three trimesters, each of seven days. Using oral dose of chloroquine 700mg/kg body weight in first second and third weeks of pregnancy.
Results:Chioroquine caused decrease in liver weight in offsprings specially in those which were exposed to drug during second and third week of pregnancy.
Conclusion:The use of chioroquine should be avoided during pregnancy

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