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Influence of Prokinetics on the Gastrointestinal Transit and Residence Times of Activated Charcoal

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Title: Influence of Prokinetics on the Gastrointestinal Transit and Residence Times of Activated Charcoal

Authors: O.E. Orisakwe , O.J. Afonne , N.A. Ilondu , E. Obi , C.S. Ufearo , P.U. Agbasi , S.O. Maduka , C.N. Orish , V.N. Orish 

Journal: Journal of Pakistan Medical Association

HEC Recognition History
Category From To
Y 2024-10-01 2025-12-31
X 2023-07-01 2024-09-30
X 2022-07-01 2023-06-30
X 2021-07-01 2022-06-30
X 2020-07-01 2021-06-30
W 2012-07-01 2020-06-30
X 2011-05-13 2012-06-30
Y 1900-01-01 2005-06-30

Publisher: Pakistan Medical Association.

Country: Pakistan

Year: 2002

Volume: 52

Issue: 8

Language: English

Categories
Drug Absorption (2) Drug Metabolism (66) Physiology (6728) Pharmacology (22872) Gastroenterology (8625)

Abstract

Abstract


Objective: To find the effects of prokinetics, saline cathartics and different charcoal doses on the gastrointestinal transit and residence times of activated charcoal (AC).
Setting: Five undergraduate volunteers of College of Health Sciences, Nnamdi Azikiwe University, Nnewi Campus, Anambra State, Nigeria, were studied.
Methods: After an overnight fast, the volunteers were given lOg and 20g AC with and without saline cathartics, in a simple cross-over design in which the subjects served as their own control. In another experiment, the volunteers received lOg AC and magnesium sulphate, with propantheline (as bromide 15mg), metoclopramide (as hydrochloride 10mg), placebo liquid or identical placebo capsule. Gastrointestinal transit and residence times of AC were recorded.
Results: Increase in the dose of AC significantly (P

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