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Abstract

Abstract


Objective: To compare the tolerability and efficacy of salbutamol and theophylline in treating wheezy infant.
Design: This was a prospective parallel group study.
Setting and subjects: Wheezy infants admitted in paediatric ward of Khulna Medical College Hospital from January 1998 to March 1999.
Main outcome variables: Palatabity of drugs, clinical efficacy of drugs and adverse events during treatment.
Results: Ninety five patients had undergone this study. Forty eight were was in salbutamol group and 47 in theophylline group. Clinical problem at the beginning was recurrent wheeze (46.3%), wheeze with fever (32.6%) and spasmodic cough (21.1%). Salbutamol was more palatable (P 0.1). Adverse effect was more frequent in theophylline treated children (47.4%) than in salbutamol group (24.4%).
Conclusion: Salbutamol is better tolerated than theophylline whereas both the drugs were equally effective for bronchodilation in infancy