DefinePK

DefinePK hosts the largest index of Pakistani journals, research articles, news headlines, and videos. It also offers chapter-level book search.

Select Collection

Antithrombotic Activity of Clove Oil

Article Information

Get PDF View Article
Login to Add in Library

Title: Antithrombotic Activity of Clove Oil

Authors: Shaikh A. Saeed , Anwar H. Gilani 

Journal: Journal of Pakistan Medical Association

HEC Recognition History
Category From To
Y 2024-10-01 2025-12-31
X 2023-07-01 2024-09-30
X 2022-07-01 2023-06-30
X 2021-07-01 2022-06-30
X 2020-07-01 2021-06-30
W 2012-07-01 2020-06-30
X 2011-05-13 2012-06-30
Y 1900-01-01 2005-06-30

Publisher: Pakistan Medical Association.

Country: Pakistan

Year: 1994

Volume: 44

Issue: 5

Language: English

Categories
Antithrombotic Agents (2) Clove Oil (1) Herbal Medicine (604) Pharmacology (22872) Cardiology (10889)

Abstract

Abstract


Clove oil inhibited human platelet aggregation induced by arachidonic acid (AA), platelet-activating factor (PAF) or collagen. Clove oil was a more effective inhibitor for aggregation induced by AA and PAP (IC50:4 and 6 uM respectively) than collagen (1C50: 132 uM). The in vivo experiments in rabbits showed that clove oil (50.100mg/kg) afforded 100% protection against PAP (11mg/kg, i.v.) and 70% protection against AA (2.0 mg/kg, i.v.)- induced thrombosis and shock due to pulmonary platelet thrombosis. It also inhibited thromboxane-A2 and 12-HETE production by human platelets incubated with [C14] AA. These results are indicative that clove oil is inhibitory of platelet aggregation and thromboxane synthesis and may act as anti- tbrombotic agent

Paper summary is not available for this article yet.

Loading PDF...

Loading Statistics...