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ANTI-TUMOR EFFECT OF HUMAN LYMPHOCYTESAND INTERLEUKLN-2

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Title: ANTI-TUMOR EFFECT OF HUMAN LYMPHOCYTESAND INTERLEUKLN-2

Authors: Farzal Anwer , Mehdi Mesri , Robert C. Rees , Shahana U. Kazmi 

Journal: Journal of Pakistan Medical Association

HEC Recognition History
Category From To
Y 2024-10-01 2025-12-31
X 2023-07-01 2024-09-30
X 2022-07-01 2023-06-30
X 2021-07-01 2022-06-30
X 2020-07-01 2021-06-30
W 2012-07-01 2020-06-30
X 2011-05-13 2012-06-30
Y 1900-01-01 2005-06-30

Publisher: Pakistan Medical Association.

Country: Pakistan

Year: 1993

Volume: 43

Issue: 3

Language: English

Categories
Cytokines (27) Lymphocytes (3) Anti-tumor Activity (1) Immunology (7543) Oncology (10297)

Abstract

ABSTRACT


We studied the anti-tumor effect of control human lymphocytes and interleukin-2 (lL-2) activated lymphocytes (lymphokine activated killer cells, LAK-cells), on two different cell lines: SW742 human colon adenocarcinoma and K562 human myeloid leukaemia cell line. Our results indicate that lL-2 augment the anti-tumor activityy of human lymphocytes and these LAK-cells lyse the tumor cells very efficiently. Furthermore, we treated the target cells (SW742 and K562) with different cytokines in order to establish whether these cytokines have any effect on susceptibility to lysis by LAK-cells. Anti-tumor activity of human lymphocytes and IL-2 is discussed in this study

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