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Abstract

ABSTRACT


Twenty patients with ultrasound diagnosed polycystic ovaries and high luteinizing hormone levels who failed to respond to clomiphene citrate were given tamoxifen to induce ovulation. Tamoxifen 20 mg daily (group 1, n=10) and 40 mg daily (group 2, n=10) was given far 5 consecutive days from the third to seventh day of the cycle. Treatment was monitored by serial ultrasound scans and assessment of serum estradial. Human charionic ganadatraphin (hCG) was administered when atleast one fallicule was >16mm and serum estradial level was >300pg/ml per fallicule. Ovulation was confirmed with detection af the follicular rupture ultrasanagraphically 2 days after hCG and midluteal progesterone levels. The ovulation rate achieved in group 2 patients was signif icantly higher (p=0.01) than group 1. Three pregnancies were achieved in group 2 patients while there was no pregnancy in group 1. The only side effect was ovarian cyst formation In one patient in group 1. As a result, tamaxifen might be a good choice for clamiphene resistant patients prior to treatment with surgery or hMG