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Abstract

Abstract


To assess the comparative efficacy of omeprazole 20 mg in the morning versus ranitidine 150mg twice a day, in the healing of duodenal ulcer, 43 endoscopicolly verified cases were randomly allocated to 2 or 4 weeks (if ulcer did not heal at 2 weeks) treatment. Two cases were excluded due to deviation from the protocol. Of 21 cases treated with ameprazale 15 (71%) healed at two weeks and all (100%) at 4 weeks. Similarly of 20 cases treated with ranitidine, 14 (70%) healed at 2 and 18 (90%) at 4 weeks (P=NS). Two patients who did not heal with ranitldlne, when crossed aver to ameprazale healed at 4 weeks. Na significant difference in the rate of pain relief, clinical or laboratory parameters are adverse effects were noted in either group. Bath the drugs were well tolerated and were patent healer of duadenal ulcer; but ameprazole appears to be superior in the healing of resistent ulcers