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Severe Bone Marrow Suppression in a Patient with Rheumatoid Arthritis on Methotrexate

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Title: Severe Bone Marrow Suppression in a Patient with Rheumatoid Arthritis on Methotrexate

Authors: M. Perwaiz Iqbal , Azra A. Alvi 

Journal: Journal of Pakistan Medical Association

HEC Recognition History
Category From To
Y 2024-10-01 2025-12-31
X 2023-07-01 2024-09-30
X 2022-07-01 2023-06-30
X 2021-07-01 2022-06-30
X 2020-07-01 2021-06-30
W 2012-07-01 2020-06-30
X 2011-05-13 2012-06-30
Y 1900-01-01 2005-06-30

Publisher: Pakistan Medical Association.

Country: Pakistan

Year: 1993

Volume: 43

Issue: 12

Language: English

Categories
Bone Marrow Suppression (1) Rheumatology (1821) Autoimmune Diseases (175) Methotrexate (9) Pharmacology (22872)

Abstract

Introduction


Methotrexate (MDC) in low doses has been com­monly and effectively used in the treatment of rheumatoid arthritis (RA)1,2. Such small weekly doses of the drug, in general, are considered to be safe and non-toxic. However, when there is impairment of renal function or in patients having altered metabolism due to infection or metabolic disease the cumulative effect of these small doses of MDC can become life threatening3,4. We report a case of severe bone marrow suppression in a rheumatoid arthritis patient on low dose MDC therapy.

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