DefinePK

Abstract

Clinical features of congenital generalized lipodystrophy, a rare disorder, first described by Zeigler1 include loss of subcutaneous fat, hepatomegaly, in­creased bone growth, hyperlipaemia and, later, diabetes. The inheritance is probably autosomal recessive2. Generalized lipodystrophy may involve the dien­cephalon. A probable defect in the hypothalamus may lead to increased levels of hypothalamic releasing factors in the peripheral blood2.