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Title: VENTRICULAR CSF IMMUNOGLOBULINS IN BRAIN TUMOURS
Authors: Kartar Dawani , Mohammad Tayyab
Journal: Journal of Pakistan Medical Association
Publisher: Pakistan Medical Association.
Country: Pakistan
Year: 1992
Volume: 42
Issue: 4
Language: English
ABSTRACT
Ventricular CSF glucose, total protein, protein electrophoresis, lgG, lgA, IgM and CSF cytology were determined in thirty seven patients with brain tumours. CSF glucose was unchanged and total protein was significantly high. Protein electrophoresis showed higher albumin and gamma globulin fractions. Mean IgG and IgA were significantly higher (Pc 0.001) in malignanttumours than in benign ones. IgM was detectable in 7 of 37 cases. The higher concentration of total protein, albumin and gamma globulin shows some degree of impairment of blood brain barrier. Increased concentration of lgG, IgA and IgM indicates humoral immune response of the brain against the tumours
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