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PEDIGREE ANALYSIS AND INVOLVEMENT OF PEROXIDASE IN SICKLE CELL DISEASE

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Title: PEDIGREE ANALYSIS AND INVOLVEMENT OF PEROXIDASE IN SICKLE CELL DISEASE

Authors: Farzana Nasir Naqvi , Samina Qasim 

Journal: Journal of Pakistan Medical Association

HEC Recognition History
Category From To
Y 2024-10-01 2025-12-31
X 2023-07-01 2024-09-30
X 2022-07-01 2023-06-30
X 2021-07-01 2022-06-30
X 2020-07-01 2021-06-30
W 2012-07-01 2020-06-30
X 2011-05-13 2012-06-30
Y 1900-01-01 2005-06-30

Publisher: Pakistan Medical Association.

Country: Pakistan

Year: 1992

Volume: 42

Issue: 8

Language: English

Categories
Peroxidase (2) Pedigree Analysis (2) Genetics (16287) Sickle Cell Disease (21) Hematology (6166)

Abstract

ABSTRACT


Routine hematological tests were performed in a family which was at risk for sickle cell disease. Cellulose acetate electrophoresis and Triton PAGE were employed to differentiate between various variants of hemoglobin. Based on the data a pedigree was constructed which indicated that few members of the respectively had received the S gene, some of them were sickle cell disease while few were sickle cell trait. Elevated levels of peroxidase enzyme in affected individuals reflect its involvement in RBCs destruction. Statistical analysis strengthen this statement

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