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OMEPRAZOLE IN SHORT TERM TREATMENT OF REFLUX OESOPHAGITIS

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Title: OMEPRAZOLE IN SHORT TERM TREATMENT OF REFLUX OESOPHAGITIS

Authors: Wasim Jafri , Zaigham Abbas , Saeed Hamid , Hasnain Shah , Haleem Khan 

Journal: Journal of Pakistan Medical Association

HEC Recognition History
Category From To
Y 2024-10-01 2025-12-31
X 2023-07-01 2024-09-30
X 2022-07-01 2023-06-30
X 2021-07-01 2022-06-30
X 2020-07-01 2021-06-30
W 2012-07-01 2020-06-30
X 2011-05-13 2012-06-30
Y 1900-01-01 2005-06-30

Publisher: Pakistan Medical Association.

Country: Pakistan

Year: 1992

Volume: 42

Issue: 12

Language: English

Categories
Reflux Esophagitis (2) Omeprazole (9) Pharmacology (22872) Treatment (79) Gastroenterology (8625)

Abstract

Omeprazole inhibits the gastric secretion by alter­ing the activity of H + /K+ ATPase1,2. The drug itself is inactive but is converted to the active form, a sulfonamide in the acid milieu of canaliculi of actively secreting gastric parietal cells3. Though the plasma half life is 60 minutes, the drug binds covalently with H+/K+ATPase and duration of action is thereafter increased to greater than 24 hours4. Distal oesophagitis is a complication of gastro-oesophageal reflux. Number and duration of episodes of reflux are important in the pahogenesis5-7. The aim of this study was to assess the efficacy of omeprazole 20 mg once daily in our patients for short term treatment of refiux oesophagitis.

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