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Abstract

A 30 years old woman developed coarse hair on the face, especially on the chin. She was married for 7 years but childless. Physical examination revealed a mass thought to be arising from the left ovary. Blood testosterone level was raised. The ovarian mass was removed atlaparotomy. It was of the size of fetal head, having smooth external surface and firm solid consistency. Light microscopic examination of haematoxylin and eosin stained sections revealed large number of cells which resembled Leydig cells and also some signet ring cells with peripheral nuclei and clear cytoplasm. Another laparotomy was performed under the suspicion of a primary carcir oma in the stomach or colon. It revealed a big firm mass arisingfrom the splenic flexure of colon. This mass was diagnosed on histopathological examination as adenocarcinoma colon. She was put on chemotherapy consisting of 5-fluorouracil 1000 mg i.v. stat, doxorubicine 60 mg i.v. stat an. cyclophosphamide 600 mg i.v. stat. The treatment was given in 5 pulses at 5-week intervals. At terminal stages, she developed malignant ascites and metastasis to the skin. She died after 6 months of diagnosis.