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Title: ISONIAZID ACETYLATION AND POLYMORPHISM IN HUMANS
Authors: Mohammad Saleem , S.A. Malik , Maqsood Ahmed , Najeeba Saleem
Journal: Journal of Pakistan Medical Association
Publisher: Pakistan Medical Association.
Country: Pakistan
Year: 1989
Volume: 39
Issue: 11
Language: English
Abstract
Phenotypes of slow and fast acetylators of isoniazid (INH) were determined in 157 subjects (80 normals and 77 patients with tuberculosis) from the twin cities of Rawalpindi and Islamabad. Plasma INH concentrations were determined chemically six hours after the drug ingestion. The findings indicate that 31.8% subjects were fast acetylators of the drug
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