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DEPRESSANT EFFECT OF PROPRANOLOL ON THE ISOLATED DIAPHRAGMATIC TISSUE OF RAT

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Title: DEPRESSANT EFFECT OF PROPRANOLOL ON THE ISOLATED DIAPHRAGMATIC TISSUE OF RAT

Authors: Shah Nawaz , Abdul Rashid , Qazi Rashid Ahmad 

Journal: Journal of Pakistan Medical Association

HEC Recognition History
Category From To
Y 2024-10-01 2025-12-31
X 2023-07-01 2024-09-30
X 2022-07-01 2023-06-30
X 2021-07-01 2022-06-30
X 2020-07-01 2021-06-30
W 2012-07-01 2020-06-30
X 2011-05-13 2012-06-30
Y 1900-01-01 2005-06-30

Publisher: Pakistan Medical Association.

Country: Pakistan

Year: 1988

Volume: 38

Issue: 7

Language: English

Categories
Propranolol (2) Diaphragmatic Tissue (1) Medicine (22336) Physiology (6728) Pharmacology (22872)

Abstract

Abstract


The effect of propranolol on the electric stimulation of rat isolated diaphragm shOwed the depres­sion of its isometric force of contraction. This depressant effect of propranolol on the rat isolated diaphragm was produced in doses much higher than the doses required for the beta adrenergic receptor blocking activity. Isoprenaline showed no effect on the rat isolated diaphragm and it did not antagonise the depres­sant effect of propranolol on the tissue. Thus depression of the rat isolated diaphragm by propranolol is not related to its beta— receptor blocking activity and as it is propranolol at high doses, it does not seem to contribute significantly to the bronchospasm produced by the administration of propranolol

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