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THE PROTECT WE EFFECT OF ASCORBIC ACID ON OXYTETRACYCLINE INDUCED NEPHROTOXICITY AND HEPATOTOXICITY

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Title: THE PROTECT WE EFFECT OF ASCORBIC ACID ON OXYTETRACYCLINE INDUCED NEPHROTOXICITY AND HEPATOTOXICITY

Authors: F. Naseer , M. Alam 

Journal: Journal of Pakistan Medical Association

HEC Recognition History
Category From To
Y 2024-10-01 2025-12-31
X 2023-07-01 2024-09-30
X 2022-07-01 2023-06-30
X 2021-07-01 2022-06-30
X 2020-07-01 2021-06-30
W 2012-07-01 2020-06-30
X 2011-05-13 2012-06-30
Y 1900-01-01 2005-06-30

Publisher: Pakistan Medical Association.

Country: Pakistan

Year: 1987

Volume: 37

Issue: 3

Language: English

Categories
Vitamin C (10) Oxytetracycline (1) Medicine (22336) Toxicology (7198) Nephrology (4362) Hepatology (3886)

Abstract

Abstract


The protective effect of Ascorbic Acid on oxytetracycline induced nephrotoxicity and hepatotoxi­city in rabbits was studied. The toxic effects of fresh versus outdated tetracycline were also studied.
Forty two rabbits were divided into 6 groups of 7 rabbits each. Group A served as control and was not given any drugs. Groups B and C were given 140 mg/kg/day of fresh (group B) or outdated (group C) tetracycline for 4 weeks. Similarly group D and E were given fresh (group D) or outdated (group E), tetracycline along with 420 mg/kg/day of Ascorbic Acid. (Group F) was given Ascorbic Acid only.
Gross and microscopic examination showed that outdated tetracycline caused more severe changes and that Ascorbic Acid protected the tissues from these changes

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