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POTENTIAL PATHOGENiC MECHANISMS OF ANIMAL-PASSED VIRULENCE-ENHANCED STRAiNS OF CAMPYLOBACTER JEJUNI/COLI

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Title: POTENTIAL PATHOGENiC MECHANISMS OF ANIMAL-PASSED VIRULENCE-ENHANCED STRAiNS OF CAMPYLOBACTER JEJUNI/COLI

Authors: Shahana U. Kazmi , Bob S. Roberson , Norman J. Stern 

Journal: Journal of Pakistan Medical Association

HEC Recognition History
Category From To
Y 2024-10-01 2025-12-31
X 2023-07-01 2024-09-30
X 2022-07-01 2023-06-30
X 2021-07-01 2022-06-30
X 2020-07-01 2021-06-30
W 2012-07-01 2020-06-30
X 2011-05-13 2012-06-30
Y 1900-01-01 2005-06-30

Publisher: Pakistan Medical Association.

Country: Pakistan

Year: 1987

Volume: 37

Issue: 4

Language: English

Categories
Pathogenicity (12) Campylobacter Jejuni/Coli (2) Virulence (4) Medicine (22336) Microbiology (14542)

Abstract

Abstract


In order to study the potential pathogenic mechanisms, live cultures, culture-f ilterates and Poly­myxin B released extracts from original and animal-passed strains of C jejunh/coli were compared by a neonatal mouse infection and in-vitro Vero-Cell cytotoxicity. The cell fractions from mouse-passed strains elaborated strong cytotonic and cytotoxic activity causing elongation, granular appearance and lysis of Vero-Cells. Only weak enterotoxic activity Was associated with the original strains. Partial neutralization of the cytotonic activity by mono-clonal anticholera toxin (CT) suggested immunological relationship between the toxins which was also demonstrated by Ouchterlony immunodiffusion using polyclonal anti-CT serum. The in-vivo significance of CT like and other toxic materials produced by Campy/obacter strains during animal-passage remains to be assessed

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