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Osmotic Fragility of Erythrocytes in Duchenne Muscular Dystrophy

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Title: Osmotic Fragility of Erythrocytes in Duchenne Muscular Dystrophy

Authors: Naeema Ansari , P.Q.R. Siddiqui 

Journal: Journal of Pakistan Medical Association

HEC Recognition History
Category From To
Y 2024-10-01 2025-12-31
X 2023-07-01 2024-09-30
X 2022-07-01 2023-06-30
X 2021-07-01 2022-06-30
X 2020-07-01 2021-06-30
W 2012-07-01 2020-06-30
X 2011-05-13 2012-06-30
Y 1900-01-01 2005-06-30

Publisher: Pakistan Medical Association.

Country: Pakistan

Year: 1984

Volume: 34

Issue: 5

Language: English

Categories
Muscular Dystrophy (6) Biochemistry (18816) Physiology (6728) Hematology (6166) Pediatrics (13616)

Abstract

Abstract


Osmotic fragility of erythrocytes was studied in ten Duchenne dystrophic patients and eight healthy controls. Lysis started in Duchenne crythrocytes at a concentration of 6.5 g/l NaC1 and in the control erythrocytes at a concentration of 5.5 gIl NaCI. At all concentrations of sodium chloride (from 6.5 g/l to 4.5 g/l) significantly greater lysis was observed in the erythrocytes of dystrophic patients. The median corpuscular fragility (MCF) was also significantly greater in Duchenne patients as compared to their controls (P < 0.001). The increased osmotic fragility in Duchenne erythrocytes provides an evidence in support of the probable generalized membrane defect that manifest the disease

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