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Stability of Suiphacetamide Eye drops at Higher Temperature

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Title: Stability of Suiphacetamide Eye drops at Higher Temperature

Authors: Tauqir Ahmad 

Journal: Journal of Pakistan Medical Association

HEC Recognition History
Category From To
Y 2024-10-01 2025-12-31
X 2023-07-01 2024-09-30
X 2022-07-01 2023-06-30
X 2021-07-01 2022-06-30
X 2020-07-01 2021-06-30
W 2012-07-01 2020-06-30
X 2011-05-13 2012-06-30
Y 1900-01-01 2005-06-30

Publisher: Pakistan Medical Association.

Country: Pakistan

Year: 1983

Volume: 33

Issue: 7

Language: English

Categories
Stability Testing (9) Public Health (41589) Pharmaceutics (452) Pharmacology (22872) Ophthalmology (4490)

Abstract

Abstract


Suiphacetamide solutions at higher temperature degrade to its hydrolysed product, sulphanilamide, with a first-order rate constant. The degraded products are identified and characterised by chromatography and spectrophotometry. Attempts are made for the evaluation of kinetics, entropy and enthal changes activation energy and frequency factors during heating of sulphacetamide solutions. The determination of these thermodynamic elements is useful in prediction of the stability of suiphacetamide eye-drop formula­tion at elevated temperatures

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