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Title: 25. Comparative efficacy of local and parenternal therapies in treatment of clinical mastitis in buffaloes
Authors: Tanveer Ahmad, Aamir Sharif, Muhammad Nadeem, Asim Faraz, Ejaz Ahmad, Muhammad Saleem Akhtar
Journal: Pure and Applied Biology (PAB)
Publisher: Bolan Society for Pure and Applied Biology
Country: Pakistan
Year: 2023
Volume: 12
Issue: 1
Language: English
The present research was planned to compare the efficacy of different therapies in the treatment of clinical mastitis in dairy buffaloes. Thirty (30) lactating buffaloes having clinical mastitis (Swollen udder / teats, hardened udder / teats, clots in milk, watery streaks along milk, painful udder / teats, edematous udder / teats, etc.) were selected. 57.77% cases had decreased appetite and reduced milk production, 32.89%, 56.57% and 10.52% cases were mild, moderate and severe, respectively. Only cases ranging 1-7 days old were selected and divided into three groups i.e. A, B and C, each containing 10 buffaloes. Group A was treated with Tylosin @ 10mg/kg body weight through parenteral (intra-muscular) route, group B was treated with Gentamycin @100 mg/teat through local (intra-mammary) route, while group C was given combination of Tylosin @ 10mg/kg body weight through intra-muscular and Gentamycin @ 100mg/teat through intra-mammary route. The efficacy of therapy was measured at 14th and at 28th Day Post Treatment through clinical and bacteriological cure rate. The clinical cure rate at 28th DPT was 80.76% in group C, followed by 72% in group A and 24% in group B. The bacteriological cure rate at 28th DPT was 76.92% in group C, followed by 64% in group B and 16% in group A. Bacteriological examination showed Staphylococcus aureus as main causative agent of mastitis. It was concluded that combined use of antibiotic therapy through intra-muscular route along with intra-mammary route provided better cure in treatment of clinical mastitis in dairy buffaloes.
Keywords: Antibiotics; Buffaloes; Mastitis; Treatment
http://dx.doi.org/10.19045/bspab.2023.120030
To compare the efficacy of different therapies in the treatment of clinical mastitis in dairy buffaloes.
Thirty lactating buffaloes with clinical mastitis were divided into three groups (n=10). Group A received Tylosin intramuscularly, Group B received Gentamycin intramammarily, and Group C received a combination of both. Clinical and bacteriological cure rates were measured at 14 and 28 days post-treatment. Microbiological examination was performed to identify causative agents.
graph TD
A[Buffalo Selection n=30] --> B[Divide into 3 Groups];
B --> C[Group A: Tylosin IM];
B --> D[Group B: Gentamycin IM];
B --> E[Group C: Tylosin IM + Gentamycin IM];
C --> F[Treatment for 5 days];
D --> F;
E --> F;
F --> G[Clinical & Bacteriological Assessment 14th & 28th DPT];
G --> H[Data Analysis];
H --> I[Conclusion: Combined Therapy Best];
The combined use of intramuscular and intramammary antibiotics (Group C) resulted in better cure rates compared to either treatment alone. This may be due to better penetration of antimicrobials into udder tissue via systemic route and high local concentrations achieved via intramammary infusion.
At 28 days post-treatment, Group C showed the highest clinical (80.76%) and bacteriological (76.92%) cure rates, followed by Group A (72% and 16%) and Group B (24% and 64%). Staphylococcus aureus was identified as the main causative agent.
The combined use of Tylosin (intramuscular) and Gentamycin (intramammary) is more effective than either treatment alone for clinical mastitis in dairy buffaloes.
1. Thirty lactating buffaloes were used in the study. Confirmed in the Materials and Methods section.
2. Group C had a clinical cure rate of 80.76% at 28th DPT. Confirmed in the Results and Discussion section.
3. Staphylococcus aureus was identified as the main causative agent of mastitis. Confirmed in the Results and Discussion section.
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