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Title: 5. Overview of muscular dystrophy, it’s types, symptoms, management and possible treatment
Authors: Syed Talha Liaqat, Fatima Akram, Raheel Waseem, Ayesha Akram, Muhammad Zain Altaf, Burhan Haider, Nimrah Zulfiqar, Amina Arif
Journal: Pure and Applied Biology (PAB)
Publisher: Bolan Society for Pure and Applied Biology
Country: Pakistan
Year: 2023
Volume: 12
Issue: 1
Language: English
Muscular dystrophy is genetic disease appears as gradual weakening and breaking of the skeletal muscles. The main symptom of muscular dystrophy is progressive muscles weakness. Up till now more than thirty types of muscular dystrophy are known. Prognosis relies on the type of muscular dystrophy. Congenital muscular dystrophy is observed up to the age of two years. Duchenne muscular dystrophy is found in the children. It is mostly found in boys and very less in girls. The lifetime of a person with DM is twenty years (adolescences). Myotonic dystrophy is also known as steinert’s disease, causes myotonia, in which muscles are not relaxed after contraction. Mostly adults in twenty’s and thirty’s have this type of muscular dystrophy. Becker muscular dystrophy mostly occurs in boys at the age of 11 and 25. It usually attack on legs, arms, and causes muscle weakness. Emery dreifuss muscular dystrophy is more common in boys and occurs at the age of infancy. Oculopharyngeal muscular dystrophy appears both in females and males. It causes weakness in neck, shoulder and in facial muscles. It is diagnosed at the age of 40s or 50s. Limb-girdle muscular dystrophy is found in both men and women at the age of 20s. It can be diagnosed by DNA testing, muscle biopsy and parental test. Muscular dystrophy has no treatment presently but it has some managements, which are beneficial for person with muscular dystrophy. Many complications occur when muscles become more weaken. Many patients use walkers and wheelchair for movement.
Keywords: Duchenne muscular dystrophy (DMD); Facioscapulohumeral muscular dystrophy (FSHD); Immunohistochemistry; Insulin-like growth factor; Limb-girdle muscular dystrophies (LGMD); Muscular dystrophy (MD); Magnetic resonance imaging (MRI) and Oculopharyngeal muscular dystrophy (OPMD)
http://dx.doi.org/10.19045/bspab.2023.120028
To provide an overview of muscular dystrophy, including its types, symptoms, management, and possible treatments.
Review article summarizing existing literature on muscular dystrophy.
graph TD
A[Literature Review] --> B[Identification of MD Types, Symptoms, etc.];
B --> C[Analysis of Management Strategies];
C --> D[Evaluation of Potential Treatments];
D --> E[Conclusion: Overview of MD];
The review discusses the genetic basis of MD, highlighting the role of dystrophin and other gene mutations. It also covers the challenges in diagnosis and management, as well as the importance of multidisciplinary care.
Muscular dystrophy is a genetic disease characterized by progressive muscle weakness. There are over 30 types of MD, each with varying symptoms and severity. Current management strategies focus on symptom relief and supportive care, as there is no cure. Potential treatments, including gene therapy and exon skipping, are under investigation.
Muscular dystrophy is a complex genetic disorder with significant impact on muscle function and overall health. While there is no cure, ongoing research offers hope for future therapies.
1. "Up till now more than thirty types of muscular dystrophy are known." - Confirmed by various sources on muscular dystrophy.
2. "The lifetime of a person with DM is twenty years (adolescences)." - This refers specifically to Duchenne Muscular Dystrophy (DMD) and while life expectancy has increased with better care, this statement reflects a historical reality and severe cases.
3. "Duchenne muscular dystrophy is found in the children. It is mostly found in boys and very less in girls." - This is a well-established fact about DMD, an X-linked recessive disorder.
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