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Abstract

This study has been carried out to discover the cause of exogenous melatonin on plasma growth hormone concentration (PGHC) in four adult Macaca mulatta (rhesus monkeys). To inspect the result of solitary dose (5mg) of exogenous melatonin on PGHC four adult individual of Macaca mulatta with mean body weight 8.62 ± 1.05 were utilized. Sharp decrease in PGHC was noticed at 105 minutes 3.13 ± 0.88 mIU/L, and 120 minutes 2.86 ± 0.87 mIU/L. The growth hormone levels recorded after every 15-minutes showed gradual decrease with the advance time. Growth hormone levels regressed negatively with time (b= - 0.9202 ± 0.071). Extremely imperative reduction have been noticed through regression analysis in growth hormone levels with the advance in time (F(1,6)=163.5,P<0.0001). Results of this study supports that melatonin sharply increases plasma growth hormone concentrations for short time and then starts decreasing.
Keywords: Melatonin, Oral, PGHC, Plasma, hormone, exogenous
http://dx.doi.org/10.19045/bspab.2021.100133