DefinePK

Abstract

The chemical composition of the essential oil of the leaves of Teclea nobilis Delile (Rutaceae) (TN), was investigated by using GC/MS. Out of fifty four peaks (representing 99.3% of the oil), twenty three components were identified, representing 62.3% of the total oil composition. The main components were Germacrene-d (19%), Ocimene isomer (13%), Guaiol (3.9%), Elemol (2.9%) and Bulnesol (2.5%). Analgesia was evident in both the acetic acid induced writhing and tail flick reaction time tests in mice. A significant antipyretic activity of oil was also observed in mice. A slow and gradual neuromuscular blocking effect was recorded on rat`s phrenic-nerve diaphragm preparation. The oil showed no anti-microbial potential on various microorganisms tested. The oil showed sedative effect on behavioural tests without causing any side effect.