DefinePK

Research Objective

To evaluate the bleeding in patients undergoing minor oral surgery procedures without stopping daily low-dose aspirin therapy.

Methodology

A descriptive cross-sectional hospital-based study was conducted from mid-April to mid-June 2021 at the Altamash Institute of Dental Medicine, Karachi, Pakistan. Participants were between 30 and 75 years old, on long-term low-dose aspirin (75-100 mg), and required minor oral surgery. Data was collected via a questionnaire and included duration of aspirin use, postoperative medications, platelet count, clotting time, normal bleeding time, and intraoperative bleeding time. Patients were divided into two groups: those continuing aspirin and those who stopped it. SPSS statistical software version 22 was used for data analysis.

Methodology Flowchart

                        graph TD
    A["Patient Recruitment 30-75 yrs, low-dose aspirin, minor oral surgery"] --> B["Preoperative Evaluation"Bleeding time, Platelet count""];
    B --> C["Data Collection"Questionnaire""];
    C --> D["Divide into Groups"Continue Aspirin vs. Stop Aspirin""];
    D --> E["Perform Minor Oral Surgery"];
    E --> F["Postoperative Monitoring & Follow-up"];
    F --> G["Data Analysis SPSS v22"];
    G --> H["Compare Bleeding Times"];
    H --> I["Conclusion"];                    

Discussion

The study supports the continuation of low-dose aspirin therapy during minor oral surgery, as it does not lead to significantly increased bleeding. Discontinuing aspirin can pose a risk of thromboembolism in patients with cardiovascular conditions. The findings align with other studies suggesting that minor oral surgical procedures can be safely performed without altering aspirin regimens.

Key Findings

The mean bleeding time for patients continuing low-dose aspirin during minor oral surgery was 5.49 ± 1.07, while for patients who stopped aspirin, it was 4.57 ± 1.07. A t-test analysis did not reveal significant statistical differences (p<0.05) between the two groups regarding bleeding time.

Conclusion

Minor oral surgical procedures can be safely performed without altering or stopping the low-dose, long-term aspirin regime.

Fact Check

1. Study Period: The study was conducted from mid-April 2021 to mid-June 2021. (Confirmed)
2. Participant Age Range: Participants were between the age group of 30 to 75 years. (Confirmed)
3. Number of Participants: 51 patients were selected for the research. (Confirmed)

Mind Map