DefinePK

Abstract

Background and Objective: Currently, the primary modalities used for the management of malignant tumors are surgery, chemotherapy, radiation, intervention, molecularly targeted medicines and traditional Chinese medicine therapy. In this study, the clinical efficacy of auricular point compression on vomiting and nausea induced by platinum-containing chemotherapy was observed to provide evidence for clinical treatment. Materials and Methods: This study randomly allocated 50 cisplatin, nedaplatin, carboplatin or oxaliplatin patients to experimental and untreated groups. The experimental group received an ear-point compression bean and Palonosetron hydrochloride injection, whereas the control group received merely an injection. Daily exams occur throughout the seven days of treatment. The KPS scores, nausea, vomiting and appetite changes from medication. Results: Auricular point compression for chemotherapy-induced nausea and vomiting: Safety and efficacy. From day 7, experimental and untreated groups had comparable nausea control on day 1 (p>0.05). Both groups had similar acute vomiting and anti-nausea effects. Day 1-7 increased appetite similarly in experimental and untreated groups. Day 2-5 bean auricular point compression helped with appetite loss after chemotherapy. The KPS life-quality scores were unchanged (p>0.05). Auricular acupoint compression did not enhance the patient’s quality of life. This research found that antiemetics causes dizziness, headaches, stomach pain and constipation. Auricular point pressure significantly reduced antiemetic drug effects in the experimental group (p<0.05), indicating potential effectiveness. Conclusion: More chemotherapy patients with nausea and vomiting may benefit from the safe ear point pressure bean.