DefinePK

Abstract

Background and Objective: Bacoside A (B-A) is the major component of Bacopa monniera which is a popular folk medicine used to treat ulcer, rheumatism and neurological disorders. The present study was aimed to investigate the renoprotective property of B-A against cisplatin-induced nephrotoxicity. Materials and Methods: Thirty-two male rats were purchased and equally divided into four groups. Control rats received only saline, cisplatin (CISP) group rats were intraperitoneally (i.p.) injected with cisplatin (7 mg kg&#150;1) on the 5th day. Whereas, rats received 10 or 20 mg kg&#150;1 of B-A orally for 10 days after CISP induction and served as treatment group (B-A 10 or 20). Results: Rats treated with B-A (10 or 20) for 10 days resulted in a significant decrease in the levels of renal markers [creatinine (Cr), blood urea nitrogen (BUN)], lipid peroxidation product, inflammatory markers [Interleukin 1beta (IL-1β), Interleukin six (IL-6), tumour necrosis factor (TNF-α) and nuclear factor kappa B (NF-κB) p65 subunit) and apoptotic markers (Caspase-3/9) on comparison with CISP group. Whereas, supplementation with B-A substantially improved (p<0.01) the antioxidant activities [catalase (CAT), superoxide dismutase (SOD), reduced glutathione (GSH)]. Moreover, the histopathological changes in renal tissue were reverted to normal upon treatment with B-A. Conclusion: Both B-A 10 and 20 showed potent renoprotective activity against cisplatin-induced nephrotoxicity. Never the less, B-A 20 displayed superior renoprotective activity than B-A 10.