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Abstract

Ethanolic extract of roots of Boerhaavia diffusa was evaluated for antistress, adoptogenic activity in albino mice, by swim endurance test and cold restrain stress. The extract improved the stress tolerance by significantly increasing the swim duration and reducing the elevated WBC, blood glucose and plasma cartisol. Immunomodulatory activity was evaluated by carbon clearance assay and delayed hypersensitivity test. The extract significantly increased carbon clearance, indicating the stimulation of reticuloendothelial system. The extract produced an increase in DTH response to SRBC in mice, which was comparable with that of Levamisol, indicating stimulatory effects on lymphocytes and accessory cell types required for the expression of reaction.