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Membrane Stabilizing Activity: A Possible Mechanism of Action for the Anti-inflammatory and Analgesic Properties of Russelia equisetiformis

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Title: Membrane Stabilizing Activity: A Possible Mechanism of Action for the Anti-inflammatory and Analgesic Properties of Russelia equisetiformis

Authors: E. O. Awe, J. M. Makinde, O. A. Olajide, O. K. Wakeel

Journal: International Journal of Pharmacology

HEC Recognition History
Category From To
Y 2021-07-01 2022-06-30
Y 2020-07-01 2021-06-30

Publisher: Asian Network for Scientific Information

Country: Pakistan

Year: 2006

Volume: 2

Issue: 4

Language: English

DOI: 10.3923/ijp.2006.447.450

Keywords: AnalgesicAnti-inflammatorymembrane stabilizationRusselia equisetiformis

Categories
Pharmacology and Pharmacy (65) Inflammation (472) Biochemistry (18816) Physiology (6728) Pharmacology (22872)

Abstract

The Methanolic extract of the whole plant of Russelia equisetiformis (10-40 mg kg-1) produced significant (p<0.05) anti-inflammatory using carrageenan-induced rat paw oedema method. The extract significantly produced analgesic effect through inhibition of acetic acid-induced writhing and significantly (p<0.05) elevated the reaction time to thermal stimulation in mice treated with extract (10-40 mg kg-1). It also significantly (p<0.05) stabilized erythrocyte membrane subjected to heat and hypotonic-induced lyses. The anti-inflammatory and analgesic activities of the extract may be due to its membrane stabilizing action.

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