Comparing the Efficacy of Platelet Rich Plasma (PRP) vs. Topical Minoxidil (5%) as Synergistic Treatment in Patients Receiving Oral Finasteride for Androgenic Alopecia

Article Information

Title: Comparing the Efficacy of Platelet Rich Plasma (PRP) vs. Topical Minoxidil (5%) as Synergistic Treatment in Patients Receiving Oral Finasteride for Androgenic Alopecia

Authors: Rozeena Tumrani, Malik Muhammad Hanif, Tahir Hassan, Nazia Hanif

Journal: Pakistan Journal of Medical Research (PJMR)

HEC Recognition History

Category	From	To
Y	2024-10-01	2025-12-31
Y	2023-07-01	2024-09-30
Y	2022-07-01	2023-06-30
Y	2020-07-01	2021-06-30
Y	1900-01-01	2005-06-30

Publisher: Health Research Institute (HRI), NIH

Country: Pakistan

Year: 2022

Volume: 61

Issue: 3

Language: English

Keywords: Androgenic alopeciaPRPfinasterideminoxidil

Abstract

Objective: To compare the efficacy of platelet rich plasma (PRP) vs. topical Minoxidil (5%) as synergistic treatments in patients receiving oral Finasteride for androgenic alopecia.
Study type, settings &amp; duration: A comparative cross sectional study was conducted at Department of Dermatology, Sheikh Zayed Hospital, Rahim Yar Khan from July 2019 to June 2020. &nbsp;
Methodology: One hundred male cases of androgenic alopecia with age more than 20 years were included. The cases were divided into two equal groups A and B. The cases in group A were treated by monthly injections of PRP for 6 months while Group B was given treatment with topical Minoxidil therapy with a dose of 1 ml twice daily for 6 months. Both groups were given Finasteride in a dose of 1 mg per day. All cases were assessed for efficacy on the basis of standardized seven-point scale for hair growth. A reduction of 2 or more grades was labelled as efficacious.
Results: The 100 male cases of androgenic alopecia were equally divided in two groups A and B . The mean age of cases in group A and B was 29.06±7.18y and 32.10±6.64 respectively with a p value of 0.45. Mean duration of alopecia was 9.64±3.04 and 10.12±3.13 months with p =0.65. In group A the treatment efficacy was observed in 39 (78%) cases and in group B efficacy was observed in 20 (40%) cases with p value of 0.0001.
Conclusion: Platelet rich plasma in combination with Finasteride is significantly better therapy than Minoxidil ...........

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Research Objective

To compare the efficacy of platelet-rich plasma (PRP) versus topical Minoxidil (5%) as synergistic treatments in patients receiving oral Finasteride for androgenic alopecia.

Methodology

A comparative cross-sectional study involving 100 male patients diagnosed with androgenic alopecia, aged over 20 years. Patients were divided into two equal groups: Group A received monthly PRP injections for 6 months, and Group B received topical Minoxidil (5%) twice daily for 6 months. Both groups were administered oral Finasteride (1 mg daily). Efficacy was assessed using a standardized seven-point scale for hair growth, with a reduction of 2 or more grades considered efficacious. Statistical analysis included Chi-square test for categorical data and independent sample t-test for numerical data, with p < 0.05 considered significant.

Methodology Flowchart

                        graph TD;
    A["Recruit 100 male patients with androgenic alopecia"] --> B["Divide into two groups"A & B""];
    B --> C["Group A: Monthly PRP injections for 6 months"];
    B --> D["Group B: Topical Minoxidil 5% BID for 6 months"];
    C --> E["Administer oral Finasteride 1mg daily to both groups"];
    D --> E;
    E --> F["Assess hair growth using 7-point scale at baseline and end of treatment"];
    F --> G["Analyze data using Chi-square and t-tests"];
    G --> H["Compare efficacy between groups"];
    H --> I["Conclude on treatment effectiveness"];

Discussion

The study suggests that Platelet-Rich Plasma (PRP) in combination with Finasteride is a significantly more effective therapy than topical Minoxidil combined with Finasteride for treating androgenic alopecia. The findings are supported by previous studies on PRP and Minoxidil, highlighting PRP as an emerging and promising treatment modality, especially when used synergistically with Finasteride.

Key Findings

Treatment efficacy was observed in 78% of cases in Group A (PRP + Finasteride) compared to 40% in Group B (Minoxidil + Finasteride), with a statistically significant p-value of 0.0001.

Conclusion

Platelet-rich plasma in combination with Finasteride is a significantly better therapy than Minoxidil with Finasteride for the treatment of androgenic alopecia.

Fact Check

* The study included 100 male cases of androgenic alopecia.
* Efficacy was observed in 78% of cases in the PRP group and 40% in the Minoxidil group.
* The study was conducted from July 2019 to June 2020.

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